Essay on The Events Leading Up to the American Revolution

In the event of America’s victory in the American Revolution lead to the birth of a new nation. However, before the American Revolution the original colonies of America were already becoming impatient with British rule. This was mostly a result of a foreign country trying to rule people an ocean apart, and by rule this meant collecting taxes Americans found unfair. This rebellion against British rule became more prevalent from the passing of the Stamp Act of 1765 created mostly by George Greenville. The passing of this tax was Britain’s way of reinforcing their authority in the colonies and lessening their financial burden. However, from British standpoint that was not the sole purpose for the acts as they also wanted to build a defense†¦show more content†¦From that moment on it was clear it had to be decided was it of Britain’s best interest to give the colonist their desired independence, or fight for their most prized possession despite their debt. Y et, from the American standpoint there was only one option and that was fight for their independence as war and cleanse America of British rule. It became to the point that if open warfare was not anticipated by most Americans, some nevertheless did what they could to make ready for it. In colony after colony militia awkwardly practiced military exercises, and patriots collected weapons and ammunition. The actions on both parts led to the official start of the impending combat with the battles of Lexington and Concord. These battles signified America’s surprising readiness to stand up against the redcoats and the divide among the two countries greatened. In addition, to America’s war effort was the creation of the First Continental Congress who were expanding on what they considered fair American rights. Yet, by calling themselves a Continental Congress was an overstatement for only it represented the thirteen colonies (Alden 42). Leading Americans to urge Canadians to join the effort for them to occupy the Americas, despite conflict that arose from the Quebec Acts. America was strong in its own way, but they were also desperate for outside support for it still resonated in their minds theyShow MoreRelatedHistorical Narratives Of The Major Events Leading Up For The American Revolution Essay2379 Words   |  10 PagesSummative Objective 1 for this Instruction: Students will use primary and secondary sources to create historical narratives of the major events leading up to the American Revolution. Summative Objective 2 for this instruction: Students will know the major events that led to the American Revolution. Means of Assessment (Describe briefly here, and attached below in each lesson): After you describe your assessment, mention how you will differentiate for a student with special needs (e.g., strugglingRead MoreThe Death Of A Shoemaker And The Tea Party By Alfred F. Young Essay1338 Words   |  6 Pages The American Revolution, today, is seen as a memorable event in history. It was a war against Britain for the independence of the thirteen colonies that began in 1775. Before the American Revolution began, there was a lot of conflict between the colonists and British authorities. The British raised revenue by establishing Acts such as the Stamp Act of 1766. The colonists were against it and tried revolting against Britain, leading to the Boston Massacre in 1770 of British soldiers shoot colonistsRead MoreThe Great Principles Of The American Revolution1689 Words   |  7 Pagescreation of the American nation became what it is today from years of struggle in which the common people, as well as the Founding Fathers, played a vital part for independence. The promise of the Revolution, a nation based on the republican ideals of liberty, independence, and equality, was to some extent achieved. Yet the great principles of the Revolution have long shaped our thoughts of what it means to be an American. All the events leading up and after the American Revolution will have effectsRead MoreThe Revolution Of The American Revolution999 Words   |  4 Pagesand 1776, resistance to imperial change turned into a full-on revolution. The American Revolution, also known as the Revolutionary War, was a time of revolting and political uprising, in which the 13 colonies separated from the British Empire, forming the independent nation known as the United States of America. Though the American Revolution began because the colonies wanted independence from Britain, many important historical events and revolts also lead to the tensions and resistance to what resultedRead MoreThe Ameri can Revolution Through British Eyes By Christopher Hibbert872 Words   |  4 PagesIn his narrative Redcoats and Rebels: The American Revolution Through British Eyes, Christopher Hibbert portrays the sequence of events that happened in the American revolution from a British perspective. The author’s main idea in this narrative is to demonstrate the war from a different point of view and to emphasize the narratives from a British audience. Mr. Hibbert’s subject in this matter of the book, illustrates the life of the American people and the British loyalist representing both sidesRead MoreThe American Revolutionary War Essay1322 Words   |  6 Pages When looking at sources for research one must analyze what is influencing the author. Sarson was writing his book leading up to 2005 in Wales, and Nellis was writing leading up to 2010 in British Columbia. Although the five-year difference in publication dates does not present any convincing possible influencers between th e two authors the locational differences between the authors does present the possibility for differing influencers. Between Wales, United Kingdom, and British Columbia, CanadaRead MoreThe Revolution Of Nicaragua s Society960 Words   |  4 PagesThe Nicaraguan Revolution from 1927 to 1979 was critical in the reconstruction of Nicaragua’s society. In an already turmoil-filled Latin America, this revolution reshaped how Latin American countries dealt with foreign occupation while helping the country form an identity[JLW1] . In Nicaragua, the people were confronted with a war against the United States and resisting the Somoza regime. They had to overcome these obstacles in an attempt to finally establish peace in society. However, their journeyRead MoreRadical Ideas Of The American Revolution946 Words   |  4 Pages Leading up to the American Revolution, were a chain of events that created a spark in the colonists to obtain independence from Great Britain. The American Revo lution could not be tied to one single event but instead by the feelings and determination brought on by this chain of disgraceful actions. Gordon S. Wood explains what he believes caused the rebellion of the American colonists from Great Britain and how those causes help explain the outcomes of the revolution in his essay, â€Å"Radical PossibilitiesRead MoreThe French Revolution And The American Revolution1254 Words   |  6 PagesThe French Revolution was an influential period of social and political upheaval in France that lasted from 1789 until 1799, and was partially carried forward by Napoleon during the later expansion of the French Empire. The Revolution overthrew the monarchy, established a republic, experienced violent periods of political turmoil, and finally culminated in a dictatorship by Napoleon that rapidly brought many of its principles to Western Europe and beyond. Inspired by liberal and radical ideas, theRead MoreThe Minutemen And Their World1275 Words   |   6 Pagesof the small town of Concord, Massauchessets. Gross describes the American Revelotion through the eyes of this community which paints a more vivid picture of the events taking place up to the war which seperated the Unite States for Great Britian through a perspective that I have never seen before. The book begins with the time leading up to the American Revolution. Just like all American colonies Concord faced hardship leading up to the war. The british imposed tariffs such as the Stamp Act and

Marlows Lack Of Restraint Essay - 1849 Words

In Joseph Conrad’s infamous novella, Heart of Darkness, the narrator listens as Marlow tells his tale of his journey in the Congo, where he comes across many different types of people, all of which he can have hugely varying opinions on. It may seem at first that he simply views the Congolese as less than himself, but his ideas of humanity are far more complex than that, and is not directly tied to race. It is not the people that he despises, but the area they inhabit. He blames their environment and gives it this eminent evil surrounding it. His is an issue with their lack of restraint to the evil and savagery of the world. Marlow’s creation of his own concept of restraint in relation to his journey informs of the major themes and ideas†¦show more content†¦As he approaches Kurtz and continues down the river and further into the Congo, Marlow accumulates around thirty native Congolese people working on his steamboat, and without a real thought he makes the ass umption and conclusion that they are all cannibals. He notes that they bring Hippo meat with them, which according to him quickly goes rotten and has to be thrown overboard. He then says, â€Å"Why in the name of all the gnawing devils of hunger they didn’t go for us—they were thirty to five—and have a good tuck-in for once, amazes me now when I think of it. They were big powerful men, with not much capacity to weigh the consequences, with courage, with strength, even yet... I saw that something restraining, one of those human secrets that baffle probability, had come into play there.† This is one of the only times that Marlow describes the native Congolese people as human. Only through first basing this off several racist stereotypes, Marlow is able for a moment to view the natives as human beings, because, in his own skewed and ridiculous view of them, he believes that they have an incredible amount of restraint to the ‘darkness’ that seems to emanate from the Congo. Their self control and resistance to the savage urges is the quality Marlow believes makes them equal to himself in the sense that they are human beings like himself. This is also telling of the grand misunderstanding of Marlow with his entire experience andShow MoreRelatedAnalysis Of Joseph Conrad s The Heart Of Darkness 1801 Words   |  8 Pagesconduct in a restrictive way, such as views on sexual restraint and a low tolerance of crime (Sanders, 2). 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As time goes on, he has finished his pamphlet, but his mental degradation has just begun. Soon, the darkness consumes him and he becomes one who â€Å"lacks restraint in his various lusts,† (Conrad, pg. 57) a savage himself. In the end, Kurtz lives in a hut surrounded by pikes adorned with the heads of the â€Å"savages† and proposes that the final solution to the suppression of their customs is to â€Å"exterminateRead MoreThe Distorted Images in Heart of Darkness4513 Words   |  19 Pagesother in front of him. Marlow’s attitude to their â€Å"cannibalism† reveals his fear, ignorance and contempt. In fact, there is no cannibal in Af rica, and he never encounters cannibals in Africa. He may learn it from others’ words. Marlow treats cannibalism as an everyday custom of the Congolese, even though he probably sees no evidence of it when he is there. On the trip upstream the white men catches glimpses of villages in which ceremonial rites are being performed. Marlow’s depiction of these experiences

Sensitive Liquid Chromatography Tandem †MyAssignmenthelp.com

Question: Discusss about the Sensitive Liquid Chromatography Tandem. Answer: Introduction: Galactosemia is a genetic disease which inhibits the systemic break down of galactose in body. It occurs due to the absence of the three enzymes namely Galactose-1-phosphate uridylyltransferase (GALT),Galactokinase (GALK) and UDP-glucose 4-epimerase (GALE) (1). Of the three variants, the clinical galactosemia is the most alarming one. These enzymes are essential for breaking down glucose or galactose in the body. Increased amount of galactose in the body could have severe consequences on the health of the patients such as liver diseases, cataracts, brain damage or even death. The symptoms of the diseases could be seen in the initial days of the birth of a new born baby itself. This disease is curable with consuming diet free of galactose and lactose. However, it can cause nutritional deficiency with so many restrictions imposed on the food. These sugars are present in many foods, so as soon as the disease is identified, dieticians or nutritionists recommend a special diet to balance out the deficiency. In the meanwhile, regular blood tests keep the metabolite levels under check. But it requires many tests to examine the speech, vision, neurological, brain, liver and other body parts to monitor the progress of the disease in the body. Galactosemia is a rare genetic disease and its incidence rate varies across the world. The incidence rate varies from 1:19,000 to 1:44,000 in Europe and the US (2). However, in Asians, the disease is seen to be very uncommon while Irish people tend to have the maximum number of cases of the same. Genetic Mutation Researchers have identified various types of the disease depending on the mutation of the gene in question. These have been explained in an elaborate manner below: Classicgalactosemia or Type 1: This is probably the most common and severe version of the disease. If suffering infants arent put on a low-galactose diet promptly, there are fair chances of death within a couple of days after the birth. The symptoms include lethargy, feeding difficulties, no weight gain, jaundice, liver damage, and abnormal bleeding, bacterial infections, and shock (3). Such patients could potentially be under increased risk of speech and vision difficulties. Female patients are likely to face complications during reproduction. In this type, the erythrocyte GALT enzyme activity is very low or completely absent, but the galactose and erythrocyte galactose-1-phosphate levels are increased and hence the patients succumb to the increased risk of diagnosed with fatal E. coli sepsis and other long complications. Hence in this case, patients need immediate medical supervision before the situation worsens. Nevertheless, the patient must be put on strict diet. I Galactokinase deficiency or Type 2: It occurs due to the absence of galactose kinase. Herein, the health complications are comparatively less than the type 1. The suffering infants may get affected by cataract but are likely to avert long term severe health complications (3). Nevertheless, the patients need to be examined before confirming as incidence of this is pretty low. Type 3: It occurs due to the absence of UDP-galactose 4-epimerase enzyme. It is very rare and can be categorized in generalized form and milder peripheral form (4). If left untreated, the sufferers of the generalized form are likely to develop cataracts during the first few months of life and may fall victim to liver, kidney and brain damage in long term (5). Clinical Symptoms Medical practitioners have long been observing the clinical symptoms amongst the victims around the world. A suffering infant would suffer from vomiting, diarrhea, lethargy, jaundice, and liver damage, blood infection and in long term, it may demonstrate poor development, hepatomegaly, and cataracts (6). These long term health complications could potentially impact the day to day life of the victims. For instance, it could impact the neurological development, or could cause death if not given medical attention. If left untreated or diet containing galactose is continuously fed during the first few days of the infant, it could threaten the survival chances of the infant. The affected infants, even at the age of one to two weeks, can succumb to the disease owing to severe escherichia (E. coli) bacteria infections. The American Liver Foundation is of the view that all the affected infants who are diagnosed with jaundice must be examined for galactosemia. The disease has poor prognosis with symptoms showing up in the first few after the birth of an infant. Though the acute symptoms are well handled after a diet free of lactose and galactose is started, many sufferers despite of the severity level of the disease during the initial days after the birth (6), continue to linger on with multiple complications such as speech difficulties, intellectual deficit, neurological issues and hypergonadotropic hypogonadism in females (7). Infants are recommended soy formula. Newborn metabolic screening (NBS) helps in identifying galactosemia in advance (1). However, this screening only detects patients with GALT enzyme activity of less than 15%. Even though the NBS averts the severity of the disease and death, there is no major impact on the long term health issues. Owing to insufficient evidence supporting the NBS, researchers are reluctant to confirm it as the most suitable tool for the disease (8). Ever since the emergence of the newborn screening (NBS) for galactosemia, many infants have been timely identified with the disease. Even after knowing positive NBS, doctors have to ascertain the exact nature of the variant of GALT deficiency. Of all, classic galactosemia is a serious case and needs prompt medical attention. Hitherto, more than 230 GALT gene mutations have been found worldwide. However, a significant proportion of the positive NBS comes in case of the Duarte biochemical variant condition. Many clinicians are of the view that Duarte variant galactosemia does not confirm the presence of the disease irrespective of the dietary intervention. Nevertheless, medical supervision is required and multiple tests must be conducted to confirm the nature of the variant. Aside from the NBS, other commonly used method is to determine the activity of GALT enzyme activity in red blood cells (RBC), and further confirmed through GALT genetic analysis (9). Most of the medical labs use radioactive assays to measure enzyme activity but it isnt capable to measuring low activity (10). As measuring the GALT activity in RBC is not reliable after blood transfusion, genetic analysis in lymphocytes is recommended. There are other diagnostic methods to measure blood galactose, RBC Gal-1-P, and/or urinary galactitol before the final diagnosis is made (9). Nutritional Management Most infants are advised to go on a diet free of lactose or galactose as soon as they are diagnosed with the disease. Hence breastfeeding is replaced with soy-based formula (11). For the later stage, food free of galactose must be fed to the infants. There is as such no restriction on other fruits and vegetables. However, the patients have to be careful about nutrient intake as products replacing milk are not sufficient to meet the nutritional requirement of the body. Some patients are put on elemental formulas but they are expensive than soy formula, and neither do they provide an exclusive benefit over soy diet. There is significant variation in the level of restrictions imposed on the applicable consumption of lactose and galactose. Hence doctors put the patients on strict diet to avoid intake of the galactose or lactose. Academic studies have indicated that small proportion of intake of such products may not do much harm. Galactose content is reported to be very meagre or negligible in some cheeses such as Emmentaler cheese from Europe and North America. They are a good source of calcium and hence most of the doctors encourage aged cheese in the diet of such patients (12). There is ongoing debate across the medical fraternity in regards of lifting strict restriction on certain safe galactose products as the patients age as it may actually harm instead of curing the disease. Conclusion Galactosemia is a rare disease which alters the normal tendency of the body to process sugar. The affected infants typically show less energy, vomiting, diarrhea, slow growth, jaundice, liver issues, and many more health complications. The disease has to be diagnosed during the initial couple of days after the birth of the baby through metabolic screening. The patients are advised to consume diet free of lactose or galactose to avoid health complications. However, there are growing concerns over nutritional deficiency given the stern restriction on food. Infants are advised soy formula or elemental formula but there are other things recommended such as old cheese to balance the nutritional level. However, the proportion of lactose varies in food products across different countries. Given that patients can become nutrition deficient, some fruits, vegetables, unfermented soy-based products, legumes, and mature cheese must be allowed. However, medical practitioners must be consulted bef ore deciding on the total nutritional value. Clinically, there is no fixed solution for nutrient management. Galactosemia patients are under long term health complications, especially brain damage. In such cases, doctors must go for examining patients for developmental quotient (DQ) and intellectual quotient (IQ) in order to monitor the growth or deterioration of the disease. Likewise, clinical assessment Management to examine the speech and vision must be scheduled in a proper way to verify the executive functioning of the body. For instance, affected children must be examined after a gap of a few years to monitor the impact of disease on the patient. Doctors must examine patients for their neurological health ever since the age of 2 or 3. There is dire need to for academicians to dig deeper to understand the disease better and figure out more solutions for the affected patients. References Serafinceanu N, Cucu IC, Serafinceanu C. Galactosemia: diagnosis and treatment. Romanian Journal of Diabetes Nutrition and Metabolic Diseases. 2012 Jun 1;19(2):215-8. Coss KP, Doran PP, Owoeye C et al. Classical Galactosaemia in Ireland: incidence, complications and outcomes of treatment. J Inherit Metab Dis. 2012. 36:217. National Institute of Health (NIH). N.d . Retrieved from https://ghr.nlm.nih.gov/condition/galactosemia#statistics Timson DJ. The structural and molecular biology of type III galactosemia. IUBMB life. 2006 Feb 1;58(2):83-9. Wohlers, T M, Christacos, N C, Harreman, M T, and FridovichKeil, J L. Identification and characterization of a mutation, in the human UDP-galactose-4-epimerase gene, associated with generalized epimerase-deficiency galactosemia. Am. J. Hum. Genet.1999. 64, 462 470. Hughes J, Ryan S, Lambert D et al. Outcomes of siblings with classical galactosemia. J Pediatr . 2009. 154:721726 Kaufman FR, Reichardt JK, Ng WG et al. Correlation of cognitive, neurologic, and ovarian outcome with the Q188R mutation of the galactose-1-phosphate uridyltransferase gene. J Pediatr. 1994. 125:2257 Varela-Lema L, Paz-Valinas L, Atienza-Merino G et al. Appropriateness of newborn screening for classic galactosaemia: a systematic review. J Inherit Metab Dis. 2016. 1 17. Welling L, Bernstein LE, Berry GT, Burlina AB, Eyskens F, Gautschi M, Grnewald S, Gubbels CS, Knerr I, Labrune P, van der Lee JH. International clinical guideline for the management of classical galactosemia: diagnosis, treatment, and follow-up. Journal of inherited metabolic disease. 2017 Mar 1;40(2):171-6. Li Y, Ptolemy AS, Harmonay L et al. Ultra fast and sensitive liquid chromatography tandem mass spectrometry based assay for galactose-1-phosphate uridylyltransferase and galactokinase deficiencies. Mol Genet Metab. 2011. 102:3340. Jumbo-Lucioni PP, Garber K, Kiel J et al. Diversity of approaches to classic galactosemia around the world: a comparison of diagnosis, intervention, and outcomes. J Inherit Metab Dis. 2012. 35:103749. Portnoi PA, MacDonald A. Determination of the lactose and galactose content of cheese for use in the galactosaemia diet. J Hum Nutr Diet. 2009. 22:400408